是好是坏？
低剂量阿司匹林
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shepherd17
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Re: 低剂量阿司匹林
AI 汇总
Current high‑quality evidence shows aspirin does not extend lifespan or healthy lifespan in people without cardiovascular disease, and in older adults it may even increase mortality and bleeding risk. Its longevity benefits seen in lab studies do not translate into humans.
What the best evidence shows
What the best evidence showsThe most rigorous data come from the ASPREE randomized controlled trial and its long‑term extension ASPREE‑XT, which specifically tested whether daily low‑dose aspirin improves healthy lifespan in older adults.
Key findings
- No improvement in healthy lifespan (disability‑free, dementia‑free survival) in adults ≥70 taking aspirin vs placebo. thelancet.com
- No reduction in all‑cause mortality; hazard ratio around 0.95, meaning no statistically significant benefit. thelancet.com
- No reduction in dementia or cognitive decline. thelancet.com
- No reduction in cardiovascular events in healthy older adults. nia.nih.gov
- Increased major bleeding, especially gastrointestinal and intracranial. nia.nih.gov
- Higher cancer‑related mortality in the aspirin group in ASPREE (unexpected; still under investigation). nia.nih.gov
Why people thought aspirin might extend lifespan
Why people thought aspirin might extend lifespanLaboratory and animal studies suggested aspirin could:
- Reduce chronic inflammation
- Modulate cellular senescence
- Influence oxidative stress pathways
These mechanisms led to speculation about pro‑longevity effects, but human trials have not confirmed this. thelancet.com
Age matters — and not in aspirin’s favor
Age matters — and not in aspirin’s favorIn adults over 60, the risk of bleeding rises faster than the cardiovascular benefit, which is why many guidelines now recommend against starting aspirin for primary prevention in this age group. mayoclinic.org
There is some exploratory evidence that people over 80 might benefit more, but this is not confirmed and remains speculative. thelancet.com
When aspirin does improve survival
When aspirin does improve survivalAspirin does reduce mortality and major cardiovascular events in secondary prevention—that is, people who already had:
- A heart attack
- A stroke
- Coronary artery disease
In these cases, aspirin clearly improves survival, but this is not “longevity enhancement”—it is prevention of recurrent events. mayoclinic.org
Risks that counteract longevity
Risks that counteract longevity- Major bleeding (3.8% on aspirin vs 2.7% on placebo in ASPREE). nia.nih.gov
- Hemorrhagic stroke risk increases. mayoclinic.org
- Gastrointestinal ulcers and bleeding. mayoclinic.org
- Possible increased cancer mortality (ASPREE finding; still debated). nia.nih.gov
These risks directly undermine any theoretical longevity benefit.
Bottom line
Bottom lineAspirin does not extend lifespan or healthy lifespan in people without cardiovascular disease.
For older adults, especially ≥70, aspirin may increase harm, not reduce it.
Its only proven survival benefit is in secondary prevention of cardiovascular disease.
Re: 低剂量阿司匹林
谢谢
如果脑梗发作，不知道现在医生是不是会开低剂量asprin
shepherd17 写了： 今天, 11:39AI 汇总
Current high‑quality evidence shows aspirin does not extend lifespan or healthy lifespan in people without cardiovascular disease, and in older adults it may even increase mortality and bleeding risk. Its longevity benefits seen in lab studies do not translate into humans.
The most rigorous data come from the ASPREE randomized controlled trial and its long‑term extension ASPREE‑XT, which specifically tested whether daily low‑dose aspirin improves healthy lifespan in older adults.
Key findings
- No improvement in healthy lifespan (disability‑free, dementia‑free survival) in adults ≥70 taking aspirin vs placebo. thelancet.com
- No reduction in all‑cause mortality; hazard ratio around 0.95, meaning no statistically significant benefit. thelancet.com
- No reduction in dementia or cognitive decline. thelancet.com
- No reduction in cardiovascular events in healthy older adults. nia.nih.gov
- Increased major bleeding, especially gastrointestinal and intracranial. nia.nih.gov
- Higher cancer‑related mortality in the aspirin group in ASPREE (unexpected; still under investigation). nia.nih.gov
Laboratory and animal studies suggested aspirin could:
- Reduce chronic inflammation
- Modulate cellular senescence
- Influence oxidative stress pathways
These mechanisms led to speculation about pro‑longevity effects, but human trials have not confirmed this. thelancet.com
In adults over 60, the risk of bleeding rises faster than the cardiovascular benefit, which is why many guidelines now recommend against starting aspirin for primary prevention in this age group. mayoclinic.org
There is some exploratory evidence that people over 80 might benefit more, but this is not confirmed and remains speculative. thelancet.com
Aspirin does reduce mortality and major cardiovascular events in secondary prevention—that is, people who already had:
- A heart attack
- A stroke
- Coronary artery disease
In these cases, aspirin clearly improves survival, but this is not “longevity enhancement”—it is prevention of recurrent events. mayoclinic.org
- Major bleeding (3.8% on aspirin vs 2.7% on placebo in ASPREE). nia.nih.gov
- Hemorrhagic stroke risk increases. mayoclinic.org
- Gastrointestinal ulcers and bleeding. mayoclinic.org
- Possible increased cancer mortality (ASPREE finding; still debated). nia.nih.gov
These risks directly undermine any theoretical longevity benefit.
Aspirin does not extend lifespan or healthy lifespan in people without cardiovascular disease.
For older adults, especially ≥70, aspirin may increase harm, not reduce it.
Its only proven survival benefit is in secondary prevention of cardiovascular disease.
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shepherd17
- 精英
- 帖子： 6035
- 注册时间： 2023-12-24
- Has thanked： 973 time
- Been thanked： 821 time
Re: 低剂量阿司匹林
如果是急性脑梗，急救医生一般会用特效化血栓药 - tPA (tissue plasminogen activator，商品名各种各样) 。但治疗使用时间窗口很关键，错过最佳时间后，医生就不用这个药了。
慢性、比较轻微的脑梗，银杏叶子或银杏叶子提取物有效。银杏叶子活性物质对急性脑梗有用已经得到临床试验确证 (https://pubmed.ncbi.nlm.nih.gov/32349519/)。Costco 或 Sam's Club 有卖银杏叶子粉末胶囊 (Ginkgo biloba capsule)，国内应该也有。几十年前，我一亲戚急性脑梗，经医院急救后活下来了，但全身右半侧瘫痪。他用干银杏叶泡茶，平时坚持服用，过了2年后右手右脚渐渐恢复运动能力。后来我父亲遇到类似情形，但没有瘫痪，CT 检查发现脑部有硬币大小的梗阻阴影。他也坚持用干银杏叶泡茶喝，有一天他觉得受脑梗阻影响的半身突然变暖，手脚也恢复了力气。去医院检查，医生告诉他梗阻阴影消失了。
不过银杏叶最好不要与其它化血栓药物同时使用，以免引起出血。
上次由 shepherd17 在 14 6月 2026, 16:40，总共编辑 1 次。
Re: 低剂量阿司匹林
shepherd17 写了： 47 分钟前如果是急性脑梗，急救医生一般会用特效化血栓药 - tPA (tissue plasminogen activator，商品名各种各样) 。但治疗使用时间窗口很关键，错过最佳时间后，医生就不用这个药了。
慢性、比较轻微的脑梗，银杏叶子或银杏叶子提取物有效。银杏叶子活性物质对急性脑梗有用已经得到临床试验确证 (https://pubmed.ncbi.nlm.nih.gov/32349519/)。Costco 或 Sam's Club 有卖银杏叶子粉末胶囊 (Ginkgo biloba capsule)，国内应该也有。几十年前，我一亲戚急性脑梗，经医院急救后活下来了，但全身右半侧瘫痪。他用干银杏叶泡茶，平时坚持服用，过了2年后右手右脚渐渐恢复运动能力。后来我父亲遇到类似情形，但没有瘫痪，CT 检查发现脑部有硬币大小的梗阻阴影。他也坚持用干银杏叶泡茶喝，有一天他觉得受脑梗阻影响的半身突然变暖，手脚也恢复了力气。去医院检查，医生告诉他梗阻阴影消失了。
不过银杏叶最好不要与其它花栓药物同时使用，以免引起出血。
这个收藏了，备着